Jan 30, 2005 · Decision-making impairments in patients with pathological gambling Recent research with the Iowa Gambling Task suggests decision-making impairments in PG. These deficits are usually attributed to disturbances in feedback processing and associated functional alterations of the. Dec 06, 2010 · The orbitofrontal cortex and the dopaminergic system are structures involved in managing impulsivity and sensibility to reinforcements, and both are typically impaired in Parkinson's. Here we show that patients with both diagnoses demonstrate even greater decision-making impairment, impulsiveness, and drug use severity. The decision-making impairment may be driven by greater insensitivity to loss and choice inconsistency. It is possible that both disorders are manifestations of an underlying behavioral disinhibitory trait. Background and purpose: Pathological gambling PG in Parkinson’s disease PD is a frequent impulse control disorder associated mainly with dopamine replacement therapy. As impairments in decision‐making were described independently in PG and PD, the objective of this study was to assess decision‐making processes in PD patients with and without PG. Jul 01, 2014 · DM under risk is impaired in patients with MS.Game of dice task results. A Total percentage of advantageous or disadvantageous choices for patients with multiple sclerosis MS and healthy controls. Choosing one or two dice was considered a disadvantageous choice. See table 3 for SEM and associated p values.
Overall, the current study demonstrates that PACG patients appear to have poor decision-making skills under risky conditions and those neuroticism traits may play a role in this risk-taking behavior. Negative feedback processing, which is related to risk-taking decision-making, is also impaired in PACG patients. been associated with impairments in decision making. Moreover, in recent years, it has been demonstrated that decision making during the IGT task is more cognitively Received March 20, 2012; revised July 5, 2012; accepted July 8, 2012. Address correspondence to Dr. Jiménez‐Murcia, Head of Pathological Gambling Unit, Department of Psychiatry. Mar 27, 2008 · In DSM-IV-R  pathological gambling PG is defined as an impulse control disorder, characterized by persistent and maladaptive gambling behaviours, with disruptive consequences for familial, occupational and social functions. 78 M. Brand et al. / Decision-making in Parkinson’s patients risky decisions as patients with pathological gambling do . Thiel et al.  examined a small group of ﬁve PD. Apr 02, 2015 · In BN, decision-making ability was impaired in some studies [12,22,41], showing that obsessive-compulsive traits and pathological eating symptoms may be related to impaired decision-making ability, which in turn may lead to real-life risk-taking and immediate reward-seeking behavior such as binge eating and purging.
Procedures.We first assessed patients with a semistructured face-to-face interview as part of the usual protocol in our unit. This interview includes the assessment of substance abuse/ dependence and is usually performed by psychologists or psychiatrists minimum. Apr 25, 2005 · Pathological gamblers exhibit complex impairments in decision-making and executive function processes associated with the prefrontal cortex of. BACKGROUND AND PURPOSE Pathological gambling PG in Parkinson's disease PD is a frequent impulse control disorder associated mainly with dopamine replacement therapy. As impairments in decision-making were described independently in PG and PD, the objective of this study was to assess decision-making processes in PD patients with and without PG. Decision-making pro- pathological gambling in patients with Parkinson’s cesses following damage to the prefrontal cortex. disease. Movement Disorders, 246, 899–905. Mar 01, 2009 · PG showed the greatest impairment, that is, the highest percentage of WCST perseverative errors p =.023, the lowest percentage of conceptual-level responses p =.034, and the highest number of total trials administered p =.021, while BN showed the highest percentage of WCST nonperseverative errors p =.003. Both BN and PG females.
Other studies have addressed related questions using novel decision-making tasks and multiple comparison groups to gauge the severity of the impairments demonstrated by pathological gambling. For example, recent studies have shown that pathological gamblers perform less well than matched comparison subjects on measures of risk-taking behavior. Oct 28, 2014 · However, few empirical evidence of whether such nonpathological lottery gamblers NPLGs display the same impairments of decision making with pathological gamblers has been found so far. In present study, NPLGs and matched controls MCs were asked to perform the Iowa Gambling Task IGT and inter-temporal choice task ICT. Feb 01, 2015 · Decision making is a complex process that requires the integration of different neural substrates, including the orbitofrontal cortex and the amygdala.4, 11, 30, 31 Dysfunction of the orbitofrontal cortex has been detected in patients with addiction,32 with pathological gambling,32 and in patients with PD with pathological gambling.33–35. Jul 01, 2016 · Patients with semantic dementia, also known as the semantic variant of PPA, were not included, but the pathological basis of these patients can now be predicted accurately because most have underlying TAR DNA-binding protein 43 type 3 pathology. 4 The pathology of patients without semantic dementia presenting with one of the variants of a.
Different Underlying Impairments in Decision-making Following Ventromedial and Dorsolateral Frontal Lobe Damage in Humans Lesley K. Fellows and Martha J. Farah Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut St, Philadelphia, PA 19104-6241, USA Ventromedial prefrontal cortex VMF damage can lead to impaired decision. Decision-making impairment in patients with multiple sclerosis: a case–control study Mauricio F Farez, Lucía Crivelli, Ramón Leiguarda, and Jorge Correale Department of Neurology, Raúl Carrea Institute for Neurological Research FLENI, Buenos Aires, Argentina.
Dec 03, 2007 · Recent neuropsychological research indicates that patients with pathological gambling PG exhibit deficits in laboratory tasks of decision-making which are suggested to be associated with neurochemical alterations within the prefrontal cortex. Most studies that investigated the two types of decision making concomitantly in these patients demonstrated impairment in decision making under ambiguity, with preservation of decision-making under risk, as suggested in studies with pathological buyers and pathological gamblers 45, 46. Pathological gambling shares many of these characteristics, and having both diagnoses may be associated with greater problems than either diagnosis alone. We investigated whether among substance-dependent individuals, comorbid pathological gambling would be associated with worse decision making, greater impulsivity, risk taking, and drug severity. Using a specially designed “Gambling Task,” Cavedini, Riboldi, Keller, D’Annucci, and Bellodi 2002 compared decision-making behaviors mediated by the ventromedial prefrontal cortex in pathological gamblers and non-pathological controls. This week’s WAGER considers the results of this study.
Oct 25, 2019 · Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease.
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