Sorbitan Monostearate Toxicity Reports Review Hazard 2020

In rabbits, sorbitan monostearate was irritant when applied repeatedly to the skin. It was of low acute oral toxicity to rats and repeated oral administration affected the kidney, liver and blood of rats and mice, and induced gastro-intestinal disturbances in dogs and hamsters. Toxicity was reported in sub S, Hodag SMS, Liposorb S, SC, Protachem SMS, Sorbitan Monostearate, Sorbitan Laurate is the rnonoester of lauric acid and heixtol mono- and dian- hydrides derived from sorbitol. Its structural formula is one of the following:. FINAL REPORT: SAFETY ASSESSMENT OF SORBITAN ESTERS 69. Links with this icon indicate that you are leaving the CDC website. The Centers for Disease Control and Prevention CDC cannot attest to the accuracy of a non-federal website. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. ECHA maintains the C&L Inventory, but does not review or verify the accuracy of the information. For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed. Sorbitan monostearate, ethoxylated 1 - 6.5 moles ethoxylated Trade names. Other names. Long-term toxicity study of sorbitan monostearate Span 60 in mice. 1. 315. Food Additives and Contaminants Committee 1970. Report on the Review of Emulsifiers and Stabilisers in Food Regulations, 1962. Ministry of Agriculture, Fish- eries and Food. Long-term toxicity of cyclohexyl- amine hydrochloride in the rat. Fd Cosmet. ToxicoL.

The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Sorbitan monostearate is a waxy powder that is used as an emulsifier that keep water and oils mixed. It is produced from sorbitol and stearic acid, which is a normal fatty acid from vegetable or animal origin.The substance is used in the production of some food and healthcare products. It is a non-ionic surfactant with emulsifying, dispersing, and wetting functions.

The formulation and characterization of a novel anhydrous organogel formulated as a potential delivery vehicle from a solution of 2 nonionic surfactants, sorbitan monostearate and polysorbate 20 polyoxyethylene sorbitan monolaurate; Tween 20, in hexadecane at 60DGC, which cools to a white, semi-solid, thermoreversible gel at room temperature, are described. May 01, 1985 · The Sorbitan esters, including Sorbitan Stearate, Sorbitan Laurate, Sorbitan Sesquioleate, Sorbitan Oleate, Sorbitan Tristearate, Sorbitan Palmitate, and Sorbitan Trioleate, are used in cosmetic products as emulsifiers and stabilizers at concentrations normally under 5 percent. Toxicity was reported in subchronic and chronic studies at concentrations above that normally used. agents is not addressed in this safety assessment. The Panel reviewed the data from previous sorbitan ester reports, as well as additional data included in this report, to determine the safety of these ingredients. INTRODUCTION. In 1985, the Cosmetic Ingredient Review CIR Expert Panel Panel published a safety assessment of seven sorbitan. An additional review,. [Documentation provided to EFSA n. 1] report that sorbitan monostearate did not induce mutagenicity in S. Typhimurium tester strains TA98 and TA100 in the presence and absence of rat S9 metabolic activation system. The chronic oral toxicity of sorbitan monostearate was evaluated in a 2‐year feeding study using.

SAFETY DATA SHEET Revision Date 29-Jun-2018 Revision Number 1 1. Identification Product Name Sorbitan monostearate Cat No.: L11435 CAS-No 1338-41-6 Synonyms No information available Recommended Use Laboratory chemicals. Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet. sorbitan monolaurate, sorbitan monostearate and sorbitan monooleate, For sorbitan monostearate, no adverse effects were reported in rats fed 5% concentrations of the test substance in the diet for 6 weeks. The NOAEL was estimated to be 5% or approximately 2500 mg/kg/day. Sorbitan monostearate Page Number: 6 Safety glasses. Not available. Not available. CALL 310 516-8000 All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet MSDS applies only to the material as packaged. If this product is. EWG's Food Scores rates more than 80,000 foods in a simple, searchable online format to empower people to shop smarter and eat healthier. Each item in the database is scored based on three factors: nutrition, ingredient concerns and degree of processing. Check it. This is a safety assessment of polysorbates as used in cosmetics. These ingredients mostly function as surfactants in cosmetics. The safety assessment combined the polysorbates reviewed in 3 former safety assessments with polysorbates that had not been assessed for safety into 1 report. The Panel reviewed relevant data related to these ingredients.

as sorbitan monostearate E 491. The Panel considered the acute toxicity of sorbitan esters E 491, E 492, E 493, E 494 and E 495 very low. The Panel considered that in the subchronic toxicity studies on sorbitan monolaurate the effects on the weight of the kidneys, which in female rats were associated with histopathological tubular. Chemicals to Avoid. Cetyl alcohol. What it’s used for: emulsifier, emollient, foam booster, stabilizer, thickener Avoid it because: Possible eye, lung, and skin irritant What it’s made from: The spermaceti of whales or dolphins. Can also be derived from coconut. Steph weighs in: A long time ago I ordered a bucket of cetyl alcohol to experiment with. The warning labels were a bit off-putt. Sorbitan monostearate is a synthetic ester that is commonly used in the manufacture of food and health care products as a surfactant with emulsifying, dispersing, and wetting properties. It is used in yeast manufacturing to protect the yeast from excess drying and also helps rehydrate the yeast cells. Sorbitan monostearate is primarily used as an emulsifier to keep water and oils mixed. Sorbitan monostearate is used in the manufacture of food and healthcare products and is a non-ionic surfactant with emulsifying, dispersing, and wetting properties [citation needed]. Page 1 makingcosmetics R SDS Safety Data Sheet Sorbitan Stearate Safety Data Sheet according to Federal Register / Vol. 77, No. 58 / March 26, 2012 / Rules and Regulation.

Sorbitan monostearate, ethoxylated Not classified Implementation: EU Classification open all close all. Physical hazards. Explosives Reason for no classification: conclusive but not sufficient for classification Flammable gases and chemically unstable gases. Acute toxicity - oral Reason for no classification: conclusive but not sufficient. Polysorbate 60: short for polyoxyethylene-20- sorbitan monostearate this emulsifier is widely used in the food industry. Made of made of corn, palm oil and petroleum, this gooey mix can’t spoil, so it often replaces dairy products in baked goods and other liquid products.

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